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. 2017 Aug 24;5(5):e00339. doi: 10.1002/prp2.339

Figure 2.

Figure 2

(A)The dimeric structure of NGF (RCSB: 1BET) (McDonald et al. 1991) is presented in ribbon format. NGF monomers are colored blue and yellow. Structural features of the yellow NGF monomer are labeled. Orange highlights represent structural features of the blue NGF monomer which are responsible for TrkA binding. Green structural features highlighted represent areas responsible for p75NTR binding of the yellow NGF monomer. (B) Theoretical docking experiments identified a docking site for bivalent naphthalimide scaffold at loop II/IV domain of NGF. NGF is represented as a ribbon structure (RCSB: 1BET) (McDonald et al. 1991). Resides Glu41, Val42, Asn43, Ile44, Asn45, Asn46, Ser47, Val48, Phe49, Gln96, Ala97, Ala98, and Trp99 were selected to create a protomol binding domain for bivalent naphthalimide analogs represented in green.