Figure 2.

Change from baseline in FEV ₁ over time on (A) Day 1 (0–60 min), (B) Day 1 (0–24 h), and (C) Day 7 (0–36 h). The effect versus time profile for FEV₁ absolute values shows that the bronchodilatory effect of all abediterol doses (2.5 µg, 5 µg, and 10 µg) compared with placebo treatment was rapid (A) and sustained until the end of the 24‐h observation period on Day 1 (B) and until the end of the 36‐h period on Day 7 (C). All changes from baseline in FEV₁ with abediterol compared with placebo were statistically significant at all time points on Day 7 (P < 0.05, except for the 36‐h time point with abediterol 10 μg, P = 0.1871) and Day 1 (P < 0.001, except P < 0.01 for the abediterol 2.5 µg dose at 5 min). FEV₁, forced expiratory volume in 1 sec.