Table 2.
Change from baseline (LSM difference vs. placebo) in trough and peak FEV1 on Day 1 and Day 7 with abediterol
| Baseline | Mean FEV1, L (SD) | ||
|---|---|---|---|
| Abediterol 2.5 μg | 2.875 (0.352) | ||
| Abediterol 5 μg | 2.886 (0.536) | ||
| Abediterol 10 μg | 2.881 (0.410) | ||
| LSM difference vs. placebo (SE) | 95% CI | P‐value | |
| Change from baseline in trough FEV1 on Day 1, L | |||
| Abediterol 2.5 μg | 0.444 (0.084) | 0.267, 0.621 | <0.0001 |
| Abediterol 5 μg | 0.500 (0.089) | 0.311, 0.688 | <0.0001 |
| Abediterol 10 μg | 0.520 (0.098) | 0.313, 0.728 | <0.0001 |
| Change from baseline in trough FEV1 on Day 7, L | |||
| Abediterol 2.5 μg | 0.334 (0.095) | 0.132, 0.536 | 0.0029 |
| Abediterol 5 μg | 0.365 (0.097) | 0.158, 0.571 | 0.0018 |
| Abediterol 10 μg | 0.294 (0.100) | 0.081, 0.506 | 0.0098 |
| Change from baseline in peak FEV1 on Day 1, L | |||
| Abediterol 2.5 μg | 0.482 (0.063) | 0.349, 0.615 | <0.0001 |
| Abediterol 5 μg | 0.548 (0.069) | 0.402, 0.693 | <0.0001 |
| Abediterol 10 μg | 0.565 (0.082) | 0.391, 0.739 | <0.0001 |
| Change from baseline in peak FEV1 on Day 7, L | |||
| Abediterol 2.5 μg | 0.364 (0.072) | 0.211, 0.517 | 0.0001 |
| Abediterol 5 μg | 0.403 (0.084) | 0.224, 0.582 | 0.0002 |
| Abediterol 10 μg | 0.375 (0.101) | 0.160, 0.590 | 0.0020 |
Baseline = predose measurement on Day 1.
CI, confidence interval; FEV1, forced expiratory volume in 1 sec; LSM, least squares mean; SD, standard deviation; SE, standard error.