Figure 1.

Pharmacological concentrations of 17β‐estradiol (17βE) are required to relax coronary arterial rings precontracted by 60 mmol/L KCl. (A) Typical recording shows concentration‐dependent relaxation by 17βE of a KCl‐contracted arterial ring. Exposure to KCl is indicated by the horizontal line. (B) Average values (mean ± SE) for 17βE‐induced relaxation of KCl precontracted rings. Equal volumes of EtOH served as solvent control. *P < 0.05 using an unpaired t‐test, EtOH versus 17βE groups (n = 7 pigs).