Figure 1.

IC ₅₀ and CC ₅₀ of the four individual protein synthesis inhibitors in HepG2 and primary rat hepatocytes (PRH). (A–D) Cell viability was measured by standard MTT assay and expressed as viability as a percentage of untreated control. (E–H) Protein synthesis inhibition across different concentrations of inhibitors was measured by [³H]‐Leucine incorporation assay and shown as percentage of inhibition of control. Dotted line shows PRH and solid line for HepG2 cells. Dose–response curves were produced by Prism software and IC ₅₀ and CC ₅₀ values were calculated from linear regression models. Data are shown as mean ± SD from n = 3 independent experiments.