Figure 3.

Manhattan plot of a human genomic region on chromosome 3 (chr3) syntenic to the mouse candidate region. A region at 3q12 in the human genome, homologous to a candidate region on chromosome 16 in the mouse genome, contains a single nominal association with COPD. The Manhattan plot shows the location on chromosome 3 and gene annotations on the x-axis and strength of association on the y-axis. Linkage disequilibrium with the most significant SNP estimated from the CEU population (Utah residents with Northern and Western European ancestry) genotyped in the 1,000 Genomes Project is illustrated by different-colored SNPs. The plot was created with LocusZoom (version 1.1).