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. 2017 Nov;363(2):148–155. doi: 10.1124/jpet.117.242321

Fig. 1.

Fig. 1.

Intact acute, but absence of sensitized ethanol (EtOH) locomotor response in AC1KO mice (A–C), n = 6–7/group, and WT mice pretreated with the selective inhibitor NB001 (D–F), 10 mg/kg, n = 8–9/group. Average locomotor activity (A and D) and time course following acute (B and E) or challenge (C and F) EtOH (2.0 g/kg) after repeated home cage EtOH administration (2.5 g/kg, 10 injections). Data reported as percentage change relative to respective saline-only controls. WT EtOH-treated mice displayed an acute locomotor response relative to saline-only WT controls, which was significantly enhanced following sensitization. AC1KO and NB001-treated WT mice demonstrated a comparable acute locomotor response to WT EtOH controls, but failed to display a further potentiation in this response following sensitization. Locomotor activity on the acute and challenge day was unaltered by pretreatment with NB001 alone (NB001 + saline). Significance determined by two-way RM ANOVA and Sidak’s post hoc test, *P ≤ 0.05, compared with respective saline-treated controls; ¥P < 0.05, compared with WT + acute EtOH or saline + acute EtOH group; #P < 0.05, compared with WT + challenge EtOH or saline + acute (E) or challenge (D, F) EtOH group.