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In vitro PK of MMAE in the media and cellular space for GFP-MCF7 cells (green) and N87 cells (red). (A) Disposition of MMAE in the media after continuous exposure to MMAE. (B) Disposition of MMAE in the cellular space after continuous exposure to MMAE. (C) Disposition of MMAE in the media after 2-hour exposure to MMAE. (D) Disposition of MMAE in the cellular space after 2-hour exposure to MMAE. The arrow represents the washing step for the 2-hour exposure experiment.
