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In vitro PK of (A) unconjugated MMAE, (B) total MMAE, and (C) total trastuzumab in the media (upper panels) and cellular space (lower panels) of GFP-MCF7 (green) and N87 (in red) cells, after continuous and 2-hour exposures of the cells to 75 nM T-vc-MMAE.
