Table 1. Clinical cases of classical and novel HAstV detection in stool samples.
|
Patient characteristics |
HAstV characteristics |
Enteric virus stool screening |
Clinical manifestations |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient | Sex | Age | Immunodeficiency, etiology | Time between transplantation and HAstV detection | HAstV detected | Viral load (RNA copies/mL of resuspended stool) | Virus specie | Fever | Digestive symptoms, time between symptoms and HAstV detection | Type of digestive symptoms | Respiratory symptoms, time between symptoms and HAstV detection | Type of respiratory symptoms |
| 1 | M | 3.1 years | No | HAstV-MLB1 | 5.5 × E4 | Neg. | No | Yes, 2 days | Vomiting, diarrhea | Yes, 15 days | Cough | |
| 2 | F | 3.4 years | No | HAstV-MLB1 | 6.1 × E3 | Neg. | Yes | Yes, 4 days | Diarrhea, abdominal pain | No | ||
| 3 | F | 51.0 years | Yes, liver transplant recipient | 26.4 months | HAstV-MLB1 | 3.3 × E2 | Rotavirus | No | Yes, 1 day | Vomiting, diarrhea, abdominal pain | Yes, 1 day | Cough |
| 4 | M | 4.2 years | Yes, liver transplant recipient | 37.5 months | HAstV-MLB2 | 7.1 × E2 | Neg. | No | Yes, 1 day | Diarrhea | Yes, 13 days | Cough, rhinorrhea |
| 5 | F | 9.8 months | No | HAstV-MLB2 | 2.9 × E6 | Neg. | No | Yes, 14 days | Diarrhea | Yes | Cough | |
| 6 | M | 2.4 years | Yes, liver transplant recipient | 15.4 months | HAstV-MLB2 | 7.2 × E3 | Neg. | No | Yes, 21 days | Diarrhea | Yes, 10 days | Odynophagia |
| 7 | M | 38.2 years | Yes, allogeneic stem cell transplant recipient | 4.7 months | HAstV-MLB2 | 3.3 × E9 | Neg. | No | Yes, 3 days | Vomiting | No | |
| 8 | F | 1.4 months | No | HAstV-VA2 | 4.8 × E2 | Neg. | Yes | Yes, 4 days | Diarrhea | Yes, 10 days | Rhinorrhea | |
| 9 | F | 23 days | No | HAstV-VA2 | 8.4 × E2 | Enterovirus | Yes | Yes, 2 days | Diarrhea | No | ||
| 10 | M | 5.1 months | No | HAstV-VA2 | 3.4 × E2 | Neg. | No | Yes, 1 day | Diarrhea | Yes, 16 days | Cough, rhinorrhea | |
| 11 | F | 9.6 months | Yes, liver transplant recipient | 6 days | Classical HAstV undet. | 2.3 × E7 | Neg. | Yes | Yes, 1 day | Diarrhea | No | |
| 12 | M | 4.2 years | No | Classical HAstV-8 | 2.0 × E10 | Enterovirus | Yes | Yes, 2 days | Diarrhea | No | ||
| 13 | M | 4.8 years | Yes, kidney transplant recipient | 37.9 months | Classical HAstV undet. | 2.1 × E5 | Neg. | No | Yes, 4 days | Diarrhea | Yes, 7 days | Cough |
| 14 | M | 1.4 years | No | Classical HAstV-1 | 2.4 × E10 | Neg. | No | Yes, >30 days | Diarrhea | No | ||
| 15 | F | 9.9 months | No | Classical HAstV-2 | 1.0 × E11 | Neg. | No | Yes, 1 day | Vomiting, diarrhea | No | ||
| 16 | F | 6.4 months | No | Classical HAstV-1 | 5.3 × E6 | Neg. | Yes | Yes, 14 days | Vomiting, diarrhea | No | ||
| 17 | F | 3.4 years | Yes, liver transplant recipient | 20.6 months | Classical HAstV-4 | 1.6 × E9 | Neg. | Yes | Yes, 2 days | Vomiting, diarrohea | No | |
| 18 | M | 40.2 years | Yes, allogeneic stem cell transplant recipient | 25.4 months | Classical HAstV-1 | 7.5 × E9 | Neg. | No | Yes, 5 days | Diarrhea | No | |
| 19 | F | 30.4 years | No | Classical HAstV-3 | 2.0 × E10 | Neg. | No | Yes, 1 day | Vomiting, diarrhea | No | ||
| 20 | F | 53.0 years | Yes, allogeneic stem cell transplant recipient | 11.3 months | Classical HAstV-5 | 6.0 × E11 | Neg. | NA | NA | NA | NA | NA |
Abbreviations: human astrovirus, HAstV; not available, NA; negative, neg; undetermined, undet.