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Correlation between the changes in serum HBV RNA (A), HBV DNA (B), HBsAg (C), and HBeAg (D) levels and the changes in levels of intrahepatic cccDNA from baseline to 96 weeks after NUC treatment in CHB patients. HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; cccDNA, covalently closed circular DNA.
