TABLE 3.
Cross-tabulation of HR6 SOMAscan test results by the reference test for all phase II training, test, and blinded verification samples with complete metadataa
| SOMAscan (HR6) group | Reference status (FIND) | HR6 result (no.) |
Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|---|---|---|
| Pos. | Neg. | |||||||
| All (n = 616) | Pos. | 252 | 34 | 88.1 | 87 | 85.4 | 89.4 | 87.5 |
| Neg. | 43 | 287 | ||||||
| Training (n = 353) | Pos. | 149 | 17 | 89.8 | 87.7 | 86.6 | 90.6 | 88.7 |
| Neg. | 23 | 164 | ||||||
| Test (n = 86) | Pos. | 35 | 5 | 87.5 | 80.4 | 79.5 | 88.1 | 83.7 |
| Neg. | 9 | 37 | ||||||
| Verification (n = 177) | Pos. | 68 | 12 | 85 | 88.7 | 86.1 | 87.8 | 87 |
| Neg. | 11 | 86 | ||||||
a
The cutoff for separation of TB from non-TB was log odds of >0. Also shown are sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Pos., positive; Neg., negative.