Table 2.
Relapse | NRM | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate competing
risk regression |
Multivariate competing
risk regression |
Univariate competing risk
regression |
Multivariate competing
risk regression |
||||||||||
SHR
(95% CI) |
p |
SHR
(95% CI) |
p |
SHR
(95% CI) |
p |
SHR
(95% CI) |
p | ||||||
Age | 0.98 (0.97-0.99) | 0.001 | 1.00 (0.99-1.01) | 0.19 | 1.00 (0.99-1.02) | 0.460 | |||||||
Sex Matching | Sex matched | 1(Ref.) | 1(Ref.) | 1(Ref.) | 1(Ref.) | ||||||||
Male to female | 0.64 (0.49-0.83) | 0.001 | 0.67 (0.48-0.93) | 0.019 | 1.14 (0.70-1.84) | 0.598 | 1.30 (0.80-2.11) | 0.29 | |||||
Female to male | 0.75 (0.58-0.96) | 0.023 | 0.90 (0.66-1.22) | 0.514 | 2.48 (1.68-3.67) | 0.000 | 2.59 (1.70-3.95) | 0.000 | |||||
cGvHD | No | 1(Ref.) | 1(Ref.) | 1(Ref.) | 1(Ref.) | ||||||||
Limited | 0.66 (0.51-0.86) | 0.002 | 0.64 (0.47-0.89) | 0.007 | 0.92 (0.47-1.81) | 0.812 | 0.89 (0.45-1.76) | 0.742 | |||||
Extensive | 0.30 (0.24-0.39) | 0.000 | 0.31 (0.23-0.41) | 0.000 | 2.04 (1.28-3.27) | 0.003 | 1.70 (1.04-2.78) | 0.034 | |||||
CMV Risk | Low | 1(Ref.) | 1(Ref.) | 1(Ref.) | |||||||||
intermediate | .83 (0.40-1.74) | 0.63 | 0.85 (0.43-1.69) | 0.639 | 0.92 (0.28-3.01) | 0.886 | |||||||
High | 0.59 (0.39-0.89) | 0.012 | 0.61 (0.41-0.89) | 0.012 | 0.66 (.35-1.26) | 0.215 | |||||||
Primary Disease |
ALL | 1(Ref.) | 1(Ref.) | 1 (Ref.) | |||||||||
AML | 0.46 (0.38-0.57) | 0.000 | 0.45 (0.34-0.59) | 0.000 | 1.12 (0.79-1.6) | 0.520 | |||||||
CMV | No | 1(Ref.) | 1 (Ref.) | 1(Ref.) | |||||||||
Yes | 1.00 (0.81-1.25) | 0.94 | 1.54 (1.09-2.20) | 0.015 | 1.62 (1.11-2.38) | 0.013 | |||||||
aGvHD | No & I | 1(Ref.) | 1(Ref.) | 1 (Ref.) | 1(Ref.) | ||||||||
II & III | 0.87 (0.71-1.06) | 0.166 | 0.88 (0.69-1.14) | 0.350 | 1.74 (1.23-2.48) | 0.002 | 1.29 (.88-1.90) | 0.19 | |||||
Donor Type |
Full Matched Sibling |
1(Ref.) | 1 (Ref.) | ||||||||||
Others | 0.84 (0.54-1.31) | 0.455 | 0.52 (0.19-1.42) | 0.203 |
NRM, Non-Relapse Mortality; SHR, Sub-Distribution Hazard Ratio