FIG 1.

(A) Neutralization of SHIV challenge stocks AD8-EO, BaL-P4, and SF162P3 by PGT121 and/or 3BNC117. Neutralization was measured in the TZM-bl cell assay and showed that both antibodies achieved 100% neutralization of these commonly used challenge viruses. (B to D) Neutralization of SHIV-327c by bnAbs that showed neutralization plateaus below 100%, including PGT121 and 3BNC117 (B); bnAbs that neutralized SHIV-327c to 100% (C); and bnAbs that did not neutralize the SHIV at all (D). (E) Neutralization of SHIV-327c by PGT121 and 3BNC117 in a PBMC-based assay confirming similar patterns of incomplete neutralization by the two bnAbs. The values are means and standard errors of the mean (SEM).