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Direct viral FISH images of virus-host cultures. (A) Total nucleic acids are stained blue with DAPI. (B) Metallosphaera rRNA is labeled in green. (C) Viral nucleic acids are labeled in red. (D) Overlay shows the colocalization of total nucleic acids, Metallosphaera rRNA, and viral DNA and indicates that a Metallosphaera organism is the viral host. Bar, 5 μm.
