FIG 6.

A subset of strictly conserved residues differ in their surface exposure in H37N and P37N structures. Residues Y474, Y480, and P408 in H37N, which are strictly conserved among alphaherpesviruses, were proposed to form a conserved binding pocket for gK/UL20 based on a homology model of H37N (23). A close-up view of the surface in the vicinity of the putative pocket in H37N and P37N illustrates differences in surface exposure of the three strictly conserved residues. Residues are colored as follows: H37N Y474 and P37N Y384, blue; H37N Y480 and P37N Y390, cyan; and H37N P408 and P37N P329, red.