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Binding of E2661 and designed E2 proteins to neutralizing MAbs HCV1 (A), 95-2 (B), and 96-2 (C) measured by ELISA. Error bars indicate standard deviations from two independent experiments (performed for E2661 only), and half-maximal binding titer (EC50) was calculated for each interaction by curve fitting in GraphPad Prism software.
