FIG 5.

Morbidity and mortality in mice after homologous H7 challenge. Mice were immunized with CA/07-like (A), NL/219 (B), NL219Δ3 (C), or NY/107 (D) WIV. On day 49 or 63 postpriming (day 28 or 42 postboost), mice were challenged with homologous virus (infection doses shown). Mice were observed daily for morbidity and mortality for 14 days. The left graphs show the group mean weights ± SEM as a percentage of the day 0 weight. Daily statistical significance was calculated by multiple t tests. The right graphs show percent survival. Statistical significance between survival curves were calculated using the log rank (Mantel-Cox) test (P values are shown).