FIG 1.

Examples of antigen-specific, cytokine-induced, and memory-like NK cells in mice and humans/nonhuman primates (NHP). Venn diagrams represent examples of evidence for adaptive NK cells and whether these have been demonstrated as being truly antigen specific, cytokine induced, and memory-like or a combination of these. Microbial pathogens or other agents for which memory NK cells have been demonstrated are color coded. Ellipses indicated those agents that have been demonstrated in mice (dashed line) or humans/NHP (solid line). AML, acute myeloid leukemia; VLP, virus-like particles.