TABLE 1.

Alignment of DNA sequences to VZV and human genomes

Parameter	Result for sample:
	A	A	B	B	C	C	D	D
Nucleic acid used for library prepn	DNA	DNA	DNA	DNA	RNA	RNA	RNA	RNA
Targeted enrichment	No	Yes	No	Yes	No	Yes	No	Yes
Reads
Total no.	1,494,870	57,782,614	99,799,072	9,818,920	27,321,531	1,878,742	18,062,627	1,293,139
No. mapping to hg19	1,082,286	196,461	80,408,112	159,729	26,567,457	492,794	17,116,145	390,011
No. mapping to VZV strain 32 passage 72	361,609	56,834,979	15,808,173	9,531,226	122,947	1,338,040	72,251	860,067
No. of unaligned reads	50,975	751,174	3,582,787	60,877	631,127	47,908	874,231	43,062
Alignment (%) to hg19	72.40	0.34	80.57	0.62	97.24	26.23	94.76	30.16
Alignment (%) to VZV strain 32 passage 72	24.19	98.36	15.84	97.07	0.45	71.22	0.40	66.51
Unaligned (%) reads	3.41	1.30	3.59	2.31	2.31	2.55	4.84	3.33
Fold enrichment (%) of hg19		0.00		0.01		0.27		0.32
Fold enrichment (%) of VZV strain 32 passage 72		4.07		6.13		158.27		166.28