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G(α)i/o, RhoA, and ERK1/2 inhibitors impaired CB1-mediated bone marrow-derived monocyte/macrophage (BMM) polarization toward M1. The protein expression levels of M1 markers were measured by CBA (A–C) and western blot (D). *P < 0.05 compared with control, #P < 0.05 compared with the same treated group without inhibitors (n = 4).
