Fig. 2.

Liraglutide dose-dependently suppresses neointimal hyperplasia. Wild-type mice treated with vehicle or liraglutide at different doses were subject to femoral artery wire injury. The arteries were collected for morphometric analysis 26 days after injury. Cell density was calculated as the number of total cells divided by the area; a representative images of cross-sections of femoral arteries; Elastica van Gieson (EVG) staining, 200 ×; b neointimal area; c medial area; d arterial perimeter; e intima to media (I/M) ratio. The averages of three serial cross-sections were used as single data points. Arrows indicate the neointima; vehicle and liraglutide at 5.7 and 107 nmol/kg/day, n = 5; liraglutide at 17 nmol/kg/day, n = 6; *p < 0.05; **p < 0.01