Table 1.
Physiological and biochemical parameters of mice treated with vehicle or different doses of liraglutide
| Vehicle | Liraglutide (nmol/kg/day) | |||
|---|---|---|---|---|
| 5.7 | 17 | 107 | ||
| Number | 5 | 5 | 6 | 5 |
| Food intake (g/day) | 4.2 ± 0.2 | 4.1 ± 0.1 | 3.8 ± 0.2 | 4.2 ± 0.1 |
| Water intake (g/day) | 4.9 ± 0.2 | 5.2 ± 0.3 | 5.7 ± 0.1 | 4.9 ± 0.2 |
| Initial BW (g) | 21.6 ± 0.5 | 22.6 ± 0.4 | 22.9 ± 0.2 | 22.5 ± 0.5 |
| Final BW (g) | 22.5 ± 0.6 | 23.0 ± 0.8 | 24.8 ± 0.4 | 25.0 ± 0.4 |
| Pulse rate (beats/min) | 704 ± 15 | 709 ± 10 | 717 ± 14 | 707 ± 11 |
| SBP (mmHg) | 126 ± 3 | 123 ± 2 | 120 ± 5 | 125 ± 5 |
| DBP (mmHg) | 72 ± 7 | 72 ± 11 | 66 ± 11 | 82 ± 11 |
| HbA1c (%) | 5.1 ± 0.4 | 4.8 ± 0.2 | 4.7 ± 0.2 | 4.4 ± 0.1 |
| FPG (mg/dL) | 111 ± 28 | 98 ± 9 | 120 ± 12 | 112 ± 20 |
| TC (mg/dL) | 78 ± 10 | 67 ± 11 | 93 ± 5 | 91 ± 6 |
| TG (mg/dL) | 56 ± 3 | 51 ± 3 | 48 ± 3 | 61 ± 3 |
| Active GLP-1 (pmol/L) | 1.4 ± 0.2 | 2.2 ± 0.3 | 3.6 ± 0.8 | 8.4 ± 3.9*† |
Food and water intake were measured throughout the experimental period. The other parameters were evaluated at the end of the experiment, except for initial body weight (BW). Data are expressed as mean ± SEM
SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, TC total cholesterol, TG triglycerides, GLP-1 glucagon like peptide-1
* p < 0.05 vs. vehicle; † p < 0.05 vs. liraglutide 5.7 nmol/kg/day