Table 2.
Physiological and biochemical parameters of vehicle- or liraglutide-treated mice with or without N-omega-nitro-l-arginine methyl ester
| Vehicle | Liraglutide (17 nmol/kg/day) | +l-NAME (20 mg/kg/day) | ||
|---|---|---|---|---|
| Vehicle | Liraglutide (17 nmol/kg/day) | |||
| Number | 5 | 5 | 5 | 5 |
| Food intake (g/day) | 4.1 ± 0.1 | 3.6 ± 0.3 | 3.8 ± 0.1 | 4.2 ± 0.1 |
| Water intake (g/day) | 4.7 ± 0.3 | 5.3 ± 0.5 | 4.5 ± 0.1 | 5.0 ± 0.1 |
| Initial BW (g) | 22.4 ± 0.7 | 23.3 ± 0.2 | 21.7 ± 0.3 | 22.0 ± 0.6 |
| Final BW (g) | 22.9 ± 0.6 | 25.3 ± 1.0 | 22.5 ± 0.1 | 23.8 ± 0.9 |
| Pulse rate (beats/min) | 702 ± 15 | 712 ± 16 | 645 ± 30 | 660 ± 24 |
| SBP (mmHg) | 126 ± 3 | 120 ± 6 | 143 ± 3*† | 130 ± 3 |
| DBP (mmHg) | 72 ± 10 | 71 ± 13 | 97 ± 10 | 80 ± 10 |
| HbA1c (%) | 4.6 ± 0.1 | 4.5 ± 0.1 | 4.7 ± 0 | 4.7 ± 0.1 |
| FPG (mg/dL) | 121 ± 10 | 117 ± 8 | 120 ± 12 | 120 ± 14 |
| TC (mg/dL) | 89 ± 2 | 83 ± 6 | 90 ± 3 | 93 ± 2 |
| TG (mg/dL) | 49 ± 1 | 50 ± 4 | 54 ± 1 | 57 ± 2 |
Food and water intake were measured throughout the experimental period. The other parameters were evaluated at the end of the experiment, except for initial BW
l -NAME N-omega-nitro-l-arginine methyl ester
* p < 0.05 vs. vehicle; † p < 0.05 vs. liraglutide