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. 2017 Aug 3;117(7):1017–1025. doi: 10.1038/bjc.2017.250

Figure 1.

Figure 1

Representation of circulating tumour DNA detection with ddPCR for two patients with pancreatic adenocarcinoma and a KRAS mutation (p.G12D for patient 47 and p.G12V for patient 63). The graphs in (A and C) illustrate the data obtained with multiplex assays, and the graphs in (B and D) illustrate the data obtained with simplex assays. The blue and green dots represent droplets containing amplified mutant and wild-type alleles, respectively. The red dots correspond to droplets containing both mutant and wild-type alleles. The gray dots correspond to wells containing no alleles (no amplification). % circulating tumour DNA represents the fraction of mutant allele/total allele (wild-type allele+mutant allele). Abbreviation: ctDNA, circulating tumour DNA.