Table 4. Univariate and multivariate multinomial regression analyses of tumour mutation status and the site of first metastasis.

	Site of first metastasis						Univariate analysis				Multivariate analysisa
	S/IT		LN		D		LN vs S/ITb		D vs S/ITb		LN vs S/ITb		D vs S/ITb
Mutation status	n	%	n	%	n	%	RRR (95% CI)	P-value	RRR (95% CI)	P-value	RRR (95% CI)	P-value	RR (95% CI)	P-value
BRAF mutant	14	8	111	67	40	24	3.24 (1.49–7.08)	0.003	2.45 (1.02–5.88)	0.05	2.46 (1.07–5.69)	0.04	2.14 (0.84–5.48)	0.11
NRAS mutant	9	16	37	64	12	21	1.68 (0.68–4.19)	0.3	1.14 (0.39–3.33)	0.8	1.39 (0.52–3.72)	0.5	1.28 (0.41–4.03)	0.7
BRAF/NRAS WT	18	22	44	53	21	25	1.00		1.00		1.00		1.00

Abbreviations: CI=confidence interval; D=distant; LN=lymph node; RRR=relative risk ratio; S/IT=satellite/in-transit; WT=wild type.

^aMultivariate analysis was adjusted for patient sex, patient age, anatomical location of the primary tumour and histologic subtype.

^bSatellite/in-transit metastasis as the reference category.