Figure 1.

miR-29a expression correlates with glioma grades and patients’ prognoses. (A) Representative images of miR-29a ISH detection. Scale bar, 50 μm. (B) Comparisons among groups of miR-29a expression level (Labelling index, LI (%)) in the FFPE samples of 147 gliomas and 20 nontumoural control brain tissues. The miR-29a LI (%) of each sample was calculated with Leica Image Pro Plus 5.0 software according to percentage ratio of positive cell number to total cell number. The data in B are presented as the mean±s.d. ***P<0.001. (C and D) Kaplan–Meier analyses of the correlation between miR-29a and DFS (upper) or OS (under) of all grade glioma patients (C) and WHO grade IV glioblastoma patients (D). Patients were stratified into high and low expression subgroups using the median of miR-29a LIs.