Table 3. Association between history of hyperthyroidism and hypothyroidism and 5-year overall survival following a diagnosis of invasive ovarian cancer, Ovarian Cancer Association Consortium.
| Dead | Alive | HR (95% CI) a | P -value | |
|---|---|---|---|---|
| No history of hyper-or hypothyroidism | 2206 | 2832 | 1.00 (Ref) | |
| History of hyperthyroidism | 80 | 80 | 1.22 (0.97–1.53) | 0.08 |
| Duration of hyperthyroidism | ||||
| ⩽5 Years | 16 | 12 | 1.94 (1.19–3.18) | 0.01 |
| >5 Years | 56 | 62 | 1.07 (0.82–1.40) | 0.61 |
| P for trend | 0.32 | |||
| History of hypothyroidism | 315 | 309 | 1.16 (1.03–1.31) | 0.01 |
| Duration of hypothyroidism | ||||
| ⩽5 Years | 65 | 59 | 1.21 (0.95–1.56) | 0.13 |
| >5 Years | 189 | 196 | 1.12 (0.96–1.30) | 0.12 |
| P for trend | 0.08 | |||
| Use of hyperthyroid medications | ||||
| No | 360 | 306 | 1.00 (Ref) | |
| Yes | 6 | 5 | 0.69 (0.17–2.80) | 0.61 |
| Use of hypothyroid medications | ||||
| No | 351 | 306 | 1.00 (Ref) | |
| Yes | 108 | 71 | 1.04 (0.77–1.40) | 0.79 |
Abbreviations: CI=confidence interval; HR=hazard ratio; Ref=reference.
a
Adjusted for age at diagnosis (continuous), stage of disease (local, regional, distant), and study site.