Table 4. HRs for CRC-specific mortality among patients with colorectal cancer by quintile of post-diagnosis dietary insulin index stratified by relevant biomarkers.
|
Dietary insulin index |
|||||
|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | |||
| Stratification covariate | No. of patients | HR (95% CI)a | HR (95% CI)a | Pinteraction | |
| Adiponectin, μg ml−1 b | 0.47 | ||||
| ⩽6.65 | 207 | Referent | 1.59 (0.60–4.23) | 0.93 (0.33–2.65) | |
| >6.65 | 207 | Referent | 1.44 (0.50–4.15) | 2.13 (0.72–6.33) | |
| C-peptide, ng ml−1 b | 0.83 | ||||
| ⩽2.05 | 179 | Referent | 1.18 (0.43–3.20) | 1.47 (0.55–3.97) | |
| >2.05 | 178 | Referent | 1.64 (0.46–5.91) | 2.11 (0.58–7.64) | |
| IGFBP-1, ng ml−1 b | 0.21 | ||||
| ⩽20.45 | 157 | Referent | 2.00 (0.60–6.68) | 2.33 (0.67–8.08) | |
| >20.45 | 157 | Referent | 0.85 (0.26–2.80) | 1.08 (0.34–3.37) | |
Abbreviations: CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; IGFBP=insulin-like growth factor binding protein.
a
Adjusted for age at diagnosis (continuous), sex, race (White, Black, other, unknown), smoking status (never, past, current, unknown), body mass index (<18.5, 18.5–24.9, 25.0–29.9, 30.0–34.9, ⩾35.0 kg/m2, or unknown), physical activity (quintiles or unknown), alcohol intake (0, 0.1–4.9, 5.0–14.9, ⩾15.0 g/d), cancer stage (I to IV or unknown), grade of tumour differentiation (well, moderate, poor, unknown), location of primary tumour (proximal, distal, rectum, unknown) and year of diagnosis (continuous).
b
Cutpoints chosen based on median values.