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Proposed model for metabolic switch by miR-200c-SIRT2 in hPSCs During cellular reprogramming for hPSCs, which is ‘primed state’, downregulation of SIRT2 expression by miR-200c increased acetylation status of glycolytic enzymes, leading to the metabolic switch from OXPHOS to glycolysis. Roles of altered acetylation in bivalent metabolic status of naïve hPSCs should be further characterized in future. ‘AC’ indicates increased acetylation.
