Fig. 7.

Proposed role of Mus81-Mms4 interaction with RFC and PCNA. Model demonstrating importance of the interaction of the Mus81 complex with PCNA and RFC. i–ii Possible recruitment of the enzymatic complex to the damage site by interaction with PCNA. iii Stabilization of the Mus81 complex in the active conformation together with the RFC complex. iv–v Further steps of repair after DSB formation include homologous recombination-mediated single-end invasion followed by cleavage of sister chromatid junction, (vi) restoring replication or BIR