Table 7.
VAS secondary measures
| Visit | AyuFlex1 (n = 28) | AyuFlex2 (n = 33) | Placebo (n = 25) | p value | ||||
| Overall Knee Mobility | Overalla | AF1 + AF2 vs PBO | AF1 vs PBO | AF2 vs PBO | AF1 vs AF2 | |||
| Overalla | 0.577 | 0.552 | 0.344 | 0.946 | 0.341 | |||
| 0 | 69.4 (±21.2) | 69.4 (±17.6) | 68.8 (±21.8) | |||||
| 14 | 68.0 (±22.1) | 75.8 (±16.2) | 68.0 (±21.8) | 0.324 | 0.892 | 0.048 | 0.078 | |
| 42 | 75.5 (±16.3) | 78.2 (±14.9) | 70.1 (±21.6) | 0.078 | 0.249 | 0.078 | 0.474 | |
| 84 | 79.0 (±16.3) | 83.4 (±14.9) | 73.3 (±18.8) | 0.031 | 0.208 | 0.021 | 0.251 | |
| Changes to Measures of Overall Knee Mobilityb | ||||||||
| 9.6 (±21.6) | 13.9 (±18.9) | 4.6 (±17.9) | 0.201 | 0.115 | 0.351 | 0.074 | 0.391 | |
| Overall Joint Function | Overalla | AF1 + AF2 vs PBO | AF1 vs PBO | AF2 vs PBO | AF1 vs AF2 | |||
| Overalla | 0.444 | 0.199 | 0.219 | 0.367 | 0.776 | |||
| 0 | 73.3 (±20.5) | 66.6 (±23.8) | 72.0 (±20.8) | |||||
| 14 | 74.8 (±17.9) | 76.0 (±18.0) | 72.6 (±20.2) | 0.304 | 0.718 | 0.158 | 0.448 | |
| 42 | 76.2 (±15.1) | 79.0 (±19.0) | 72.6 (±22.6) | 0.388 | 0.493 | 0.059 | 0.226 | |
| 84 | 81.1 (±13.0) | 82.2 (±17.9) | 72.0 (±20.8) | 0.387 | 0.055 | 0.015 | 0.522 | |
| Changes to Measures of Overall Joint Functionb | ||||||||
| 7.8 (±21.1) | 15.5 (±24.7) | 0.0 (±21.1) | 0.038 | 0.029 | 0.215 | 0.011 | 0.182 | |
| Overall Low Back Health | Overalla | AF1 + AF2 vs PBO | AF1 vs PBO | AF2 vs PBO | AF1 vs AF2 | |||
| Overalla | 0.828 | 0.630 | 0.907 | 0.446 | 0.732 | |||
| 0 | 64.2 (±22.9) | 64.3 (±26.6) | 54.4 (±24.6) | |||||
| 14 | 71.8 (±18.3) | 68.3 (±23.4) | 55.8 (±21.2) | 0.032 | 0.017 | 0.153 | 0.405 | |
| 42 | 74.5(±22.5) | 72.4 (±23.1) | 55.8 (±21.2) | 0.007 | 0.014 | 0.024 | 0.626 | |
| 84 | 76.6 (±20.9) | 76.5 (±23.3) | 59.8 (±24.4) | 0.013 | 0.029 | 0.037 | 0.978 | |
| Changes to Measures of Low Back Healthb | ||||||||
| 12.5 (±27.1) | 12.3 (±19.6) | 5.5 (±25.0) | 0.480 | 0.224 | 0.290 | 0.285 | 0.975 | |
| Willingness to Exercise | Overalla | AF1 + AF2 vs PBO | AF1 vs PBO | AF2 vs PBO | AF1 vs AF2 | |||
| Overalla | 0.442 | 0.204 | 0.171 | 0.412 | 0.748 | |||
| 0 | 74.6 (±21.2) | 73.5 (±23.8) | 69.2 (±26.8) | |||||
| 14 | 74.3 (±17.5) | 76.0 (±20.4) | 71.0 (±23.6) | 0.687 | 0.941 | 0.577 | 0.553 | |
| 42 | 79.4 (±16.0) | 77.3 (±26.6) | 68.4 (±27.5) | 0.129 | 0.112 | 0.289 | 0.766 | |
| 84 | 82.7 (±16.8) | 82.9 (±20.8) | 71.1 (±27.9) | 0.039 | 0.108 | 0.082 | 0.861 | |
| Changes to Measures of Willingness to Exerciseb | ||||||||
| 8.1 (±21.9) | 9.5 (±19.6) | 2.0 (±27.0) | 0.434 | 0.203 | 0.331 | 0.215 | 0.809 | |
aOverall p value using mean changes over time amoung the listed group/s using a Repeated Measures ANCOVA
bThis was determined using Post Score Subtracted from Day O
Values Presented as Mean ± Standard Deviation
Values determined to be significant (p = <0.05) indicated