Skip to main content
. 2017 Sep 19;2017:4078346. doi: 10.1155/2017/4078346

Table 1.

ncRNAs causing insulin resistance related disorders.

ncRNA Disease condition Effect Description
miRNAs

miR-15a Chronic glucotoxicity Negative, prognostic/diagnostic Overexpression increases the biosynthesis of insulin. Upregulated in short term high glucose levels and downregulated in the long term [11].

miR-34a
miR-146
miR-21
miR-29
miR-200
β-cell apoptosis Negative, prognostic Critical factor leading to diseases related to insulin resistance [11].

miR-375
miR-124a
Hyperglycemia Negative, prognostic/diagnostic Suppresses target genes for insulin secretion. Affects the β-cell mass. Elevated amounts found in patients with type 2 diabetes. Targets the myotrophin mRNA [20].

miR-200a
miR-200b
miR-200c
miR-141
miR-429
miR-34a
Diabetes Negative, diagnostic Highly expressed in the pancreatic islets of diabetic mice [20].

miR-150
miR-192
miR-27a
miR-320a
miR-375
Type 2 diabetes Negative, diagnostic Upregulation is seen [20].

lncRNAs

Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Found to be a candidate for gene regulation in islets Highly conserved and abundantly expressed in pancreas and other cell types, altered regulation is seen with disease conditions [14].