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. 2017 Sep 19;2017:4078346. doi: 10.1155/2017/4078346

Table 3.

ncRNAs affecting both cardiovascular diseases and insulin resistance.

ncRNA Insulin resistance effect Cardiovascular effect Description
miR-34a Hyperglycemia Impaired angiogenesis miR-34a dependent gene regulatory system governs SIRT1 levels and eNOS modifications, both of which affect the two related disease conditions [17].

miR-134 Diabetes mellitus Microvascular structure formation and reduced cell migration Highly expressed in patients with the two disease conditions [17].

miR-130a Diabetes mellitus Endothelial Progenitor Cell (EPCs) regulation Diabetes mellitus patients show decreased proliferation, colony formation, and migration but increased apoptosis in EPCs [17].

miR-24 High glucose levels VSMC pathology miR-24 targets genes causing high glucose induced cell proliferation and migration [17].

miR-504 Diabetes mellitus VSMC dysfunction Upregulation causing both conditions in patients [17].