Skip to main content
. Author manuscript; available in PMC: 2017 Oct 3.
Published in final edited form as: Leuk Res. 2016 Aug 12;49:108–112. doi: 10.1016/j.leukres.2016.08.006

Table 2.

Chromosomal or Molecular Progression While on Therapy at the Time of BCR-ABL35INS Detection

Peripheral Blood Bone Marrow Total n=64
Increase in Ph by karyotype only 0 7 7 graphic file with name nihms878858t1.jpg
Increase in Ph by FISH only 21 5 26
Increase in PCR only 1 1 2
No. Pts with additional chromosomal abnormalities1 12 8 9
No change in FISH or PCR 13 6 19
No additional testing done 1 0 1
1

46,XX, t(9;22)(q34.1;q11.2), t(10;12)(p11.2;q21)[3]; 46,XX, t(10;12)(p11.2;q21)[17]

46,XX, t(9;22)(q34.1;q11.2), der(6)t(3;6) (q21;p23)[19] 46,XX, t(9;22)(q34.1;q11.2)[1]

46,XY, t(9;22)(q34.1;q11.2), t(1;5)(q25;q13)[20]

46,XX, t(9;22)(q34.1;q11.2) [18];47,XX,+8[2]

49,XY,+8,t(9;22)(q34.1;q11.2), +17,der(22),t(9;22)(q34.1;q11.2) [4]/46,XY[16]

46,XX, der(9) t(9;22)(q34.1;q11.2)t(6;18;22)(p21;q11.2;q12)[19]/46,XX[1]

48,XX,t(3;21)(q26;q22), ider(22)(q10) t(9;22)(q34.1;q11.2), +12,+ider(22)t(9;22)(q34.1;q11.2)[20]

2

Peripheral blood FISH: double Ph chromosome 250/500 cells (50%)

48,XY,+8, ider(22)t(9;22)(q34.1;q11.2) +19[20]