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HCV RNA and polyprotein. Conserved RNA structures in the 5’ and 3’ untranslated regions (UTR) are illustrated. The genome has a single long reading frame encoding a viral polyprotein of approximately 3000 amino acids. The polyprotein is processed co- and post-translationally by host and viral proteases to release the three structural proteins, Core, E1, and E2 (labeled in blue) and the seven non-structural proteins (labeled in red).
