Fig. 2.
Classification of identified synaptosomal proteins based on cellular localization.
(A) Simplified representation of the “cellular component” classes enriched in typical synaptosome components (predominantly from mitochondria) with p −value <10−6 (Eden et al., 2007). The original graph was modified to improve readability. Stronger enrichment is represented by lower p-values; (B) Cellular localization of unlabeled mouse synaptosome; (C) Localization of IodoTMT-labeled mouse nitrosylated synaptosome proteins; (D) Comparison to a TMT-labeled synaptosome whole proteome (independent of modification) (Engmann et al., 2010); (E) Comparison to a biotin switch technique study on synaptosomes (Zareba-Koziol et al., 2014); (F) The overlapping synaptosomal proteins of IodoTMT-labeled and TMT-labeled (Engmann et al., 2010); (G) The overlapping SNO synaptosomal proteins of IodoTMT-labeled and Biotin Switch Technique (Zareba-Koziol et al., 2014).