Figure 4.

Eradication rates evaluated with antibiotic resistance.

STFX: sitafloxacin; MTZ: metronidazole; S: susceptible; r: resistant.

Resistance to STFX or MTZ was defined as minimum inhibitory concentrations (MICs) of ≥ 0.12 or ≥8 µg/ml, respectively.

The eradication rates of each group (MTZ-S and STFX-S, MTZ-S and STFX-R, MTZ-R and STFX-S, MTZ-R and STFX-R) were 91.7% (22/24), 95.2% (20/21), 100% (7/7) and 40.0% (2/5), respectively. Chi-square test revealed there was significant difference among these four groups (p < 0.01); moreover, residual analysis showed the eradication rate of the MTZ-R and STFX-R strains was significantly lower among the group (**p < 0.01).