Figure 4.

TLR4 and tryptase protein distribution in the jejunal mucosa.

Representative micrographs of double immunostaining of tryptase (green) and TLR4 (red) in the epithelium and in the lamina propria from HS, IBS-D-NT, and IBS-D-DSCG groups. Original magnification ×100. Note TLR4 (white arrows) independent of MCs (grey arrowheads). TLR4: Toll-like receptor 4; HS: healthy subjects; IBS-D-NT: diarrhoea-predominant irritable bowel syndrome patients after six months’ follow-up with no treatment; IBS-D-DSCG: diarrhoea-predominant irritable bowel syndrome patients after six months of treatment with oral disodium cromoglycate; MCs: mast cells.