Table S2.

Standard chemotherapy compounds used in advanced CRC, mode of action, and corresponding patient plasma concentration

Chemotherapy compounds	Mode of action	Patient plasma concentration, mM	Ref.
5-FU	Blocks thymidylic acid formation; DNA biosynthesis	426.2	46
Oxaliplatin	DNA crossliking agent; preventing DNA replication and transcription	8.1	47
Folinic acid or leucoverin	Stabilizes binding of 5-FU to thymidylate synthase	18.5	48
Irinotecan	Analog of camptothecin, inhibits topoisomerase activity, blocking DNA replication, and transcription	8	49