Table S3.

Histopathology primary tumor information

Patient sample	Primary tumor location	pTNM	Observations	RELAPSE
P1	Right colon	T1N0	Conventional	—
P2	Left colon	T3N2	FO adjuvant	Yes
P3	Right colon	T3N2a	Mucinous	—
P4	Right colon	T3N1b	Mucinous	—
P5	Right colon	T3N1a	Conventional	—
P7	Left colon	pT4N0	FO adjuvant	No
P8	Right colon	pT4N0	Neoadjuvant FOLFOXIRI + FOLFOX adjuvant	No
P9	Rectum	pT3N1c	FO adjuvant	No
P10	Right colon	pT3N2a	FO adjuvant	Yes
P11	Rectum	pT1N0	No treatment	—

List of surgically resected human CRC tumors samples. Tumor node metastasis status: T1, tumor invades submucosa; T3, growth into the outermost layers of the colon. pN0, no malignant lymph nodes; pN1, cancer cells are found in one to three lymph nodes; pN1a, cancer cells in one regional lymph node; pN1b, cancer cells in two to three regional lymph nodes; pN2, cancer cells in four or more regional lymph nodes; pN2a, cancer cells are found in four to six lymph nodes. Relapse after 3 mo to 6 mo postsurgery.