TABLE 7.

Markers of kidney function, blood count, and urinary electrolyte status at study days 1 and 21

	nHMF				cHMF
Variable	n	Median	IQR	Geometric mean	n	Median	IQR	Geometric mean	P*
Urinary creatinine, μmol/L
D1	63	1300.0	785.5–1685.5	1224.7	69	1105.0	900.0–1500.0	1182.3
D21	57	1030.0	660.0–1609.0	1000.3	55	854.0	618.0–1273.0	900.8	0.447
Serum hemoglobin, mmol/L
D1	68	2.08	1.84–2.29	2.14	72	2.02	1.84–2.26	2.18
D21	63	1.71	1.56–1.91	1.83	66	1.69	1.50–1.98	1.76	0.936
Serum hematocrit, %
D1	68	0.40	0.35–0.43	0.39	72	0.39	0.35–0.43	0.38
D21	63	0.32	0.29–0.38	0.33	66	0.33	0.28–0.38	0.33	0.805
Urinary sodium, mmol/L
D1	66	37.0	23.3–57.3	37.5	69	32.0	19.4–54.0	31.2
D21	59	34.0	21.1–48.0	33.3	56	23.0	14.3–36.4	24.0	0.037
Urinary potassium, mmol/L
D1	66	25.9	13.6–37.0	23.6	69	21.8	15.0–32.2	20.0
D21	59	30.0	16.9–45.0	27.6	57	22.9	16.9–30.4	22.8	0.040
Urinary chloride, mmol/L
D1	60	37.0	26.3–60.0	40.2	67	33.0	20.5–55.0	34.2
D21	54	31.0	17.8–43.8	30.7	55	26.0	18.0–39.5	27.8	0.558

cHMF = control human milk fortifier; D1 = study day 1; D21 = study day 21; IQR = interquartile range; nHMF = new human milk fortifier .

^*D21 geometric mean values were log-transformed and analyzed using analysis of covariance (adjusting for the relevant biochemical measure at D1, sex, and center).