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. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: Circ Res. 2017 Sep 15;121(7):731–748. doi: 10.1161/CIRCRESAHA.116.309396

Figure 6.

Figure 6

Shown are major components within the cardiomyocyte with emphasis on compartments that contribute to genetically mediated DCM. The extracellular matrix is shown in gray. The dystrophin complex that includes the sarcoglycans (green) is mutated in forms of DCM with neuromuscular disease. The sarcomeres (pink) include components that are mutated in both HCM and DCM. Z band (dark red) is a mechanosensing hub that serves to transmit force from the sarcomeres. Mutations in both mitochondrially encoded (purple) and nuclear encoded mitochondria proteins lead to cardiomyopathy. The nuclear lamina include lamins A and C, and the gene LMNA is commonly mutated in DCM.