Table 2.
Top Canonical pathways in BMDMs during infection with either hypo- or hypervirulent M.tb.
| Hypervirulent infected BMDMs | ||
|---|---|---|
| Pathway | p-value | Overlap |
| Role of BRCA1 in DNA Damage Response | 4.79E − 14 | 44.9% 35/78 |
| Hereditary Breast Cancer Signaling | 6.50E − 14 | 36.5 % 46/126 |
| Mismatch Repair in Eukaryotes | 6.91E − 14 | 93.8 % 15/16 |
| Cell Cycle Control of Chromosomal Replication | 2.18E − 13 | 73.1% 19/26 |
| GADD45 Signaling | 2.93E − 10 | 73.7 % 14/19 |
| Hypovirulent infected BMDMs | ||
| Pathway |
p-value |
Overlap |
| Cell Cycle Control of Chromosomal Replication | 1.36E − 12 | 73.1 % 19/26 |
| Role of BRCA1 in DNA Damage Response | 1.59E − 10 | 41.0 % 32/78 |
| Hereditary Breast Cancer Signaling | 7.45E − 09 | 31.7 % 40/126 |
| Mismatch Repair in Eukaryotes | 1.34E − 08 | 75.0 % 12/16 |
| Cell Cycle:G2M DNA Damage Checkpoint Regulation | 4.75E − 07 | 40.8% 20/49 |