Table 3.

Upstream regulators and their predicted activation in BMDMs during infection with either hypo- or hypervirulent M.tb.

	HYPOVIRULENT M.tb infection
Upstream regulator	p value of overlap	Predicted activation
PTGR4	1.85E − 49	Inhibited
CSF2	2.37E − 48	Activated
TICAM1	2.48E − 32	Activated
IRF3	7.70E − 31	Activated
IRF7	1.02E − 28	Activated
	HYPERVIRULENT M.tb infection
PTGR4	7.41E − 52	Inhibited
CSF2	1.30E − 45	Activated
TICAM1	2.31E − 38	Activated
IRF3	2.87E − 38	Activated
TLR4	8.98E − 37	Activated