Table 2.
Virulence genes examined in this study.
| Gene | Product | Function/Characteristics | Reference |
|---|---|---|---|
| sodA | Mn-cofactored superoxide dismutase | Converts superoxide anions to molecular oxygen and hydrogen peroxide | 16 |
| ponA | Penicillin-binding protein 1a | Promotes resistance to antimicrobial peptides. | 52 |
| cylE | CylE protein | Predicted to function as a N-acyltransferase in the biosynthesis of the GBS pigment granadaene required for hemolytic/cytolytic activity of GBS. | 53 |
| covR | DNA-binding response regulator CovR | Two component regulatory system response regulator involved in virulence | 54 |
| covS | Sensor histidine kinase covS | Two component regulatory histidine kinase involved in virulence | 54 |
| scpB | C5a peptidase | Dual function: cleaves and inactivates complement; promotes binding to epithelial cells and fibronectin. | 28 |
| lmb | Laminin-binding protein | Promotes GBS colonization and translocation into bloodstream. | 29,52 |
| fbsA | Fibrinogen-binding protein A | Promotes adherence to epithelial cells | 30 |