Figure 4.

Behavioral impairment in the TMEM16B KO mice. In “find the buried cookie test” (A) a piece of Oreo cookie was buried under the cage bedding and the mouse when introduced into the cage was free to explore to find the cookie. TMEM16B KO mice were slower initially compared with WT but over the following days they improved and accomplished the task as fast as the WT (B, compare day 1 with day 4). When a new food item was buried the TMEM16B KO mice were again slower than the WT (B and C). Modified from Pietra et al. 2016 originally published in the Journal of General Physiology with permission.⁸⁷