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. 2017 Oct 2;214(10):2947–2966. doi: 10.1084/jem.20160974

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© 2017 Kang et al.

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Figure 9. — Recovery of social interaction deficits and stereotyped behaviors by chronic treatment with 7,8-DHF in VRK3-KO mice. (A) Duration of grooming behavior 1 wk (test 1) after final chronic treatment with 7,8-DHF or vehicle in WT and VRK3-KO mice (n = 5–7 for WT and VRK3-KO mice; ***, P < 0.001; **, P < 0.01; t test). (B and C) Sociability and preference for social novelty at 1 wk (test 1) after final chronic treatment with 7,8-DHF or vehicle, sociability with mouse 1 (blank bar) versus object (filled bar; B: n = 6, 7 and 6, 9 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,48 = 31.50, P < 0.0001, interaction F_3,48 = 7.17, P = 0.0005, two-way ANOVA; ***, P < 0.001; **, P < 0.01, Bonferroni’s post-test), and preference for social novelty with familiar mouse (blank bar) versus novel mouse (filled bar; C: n = 6, 7 and 6, 9 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,48 = 25.13, P < 0.0001, two-way ANOVA; *, P < 0.05, Bonferroni’s post-test). (D and E) Sociability and preference for social novelty at 5 wk (test 2) after final chronic treatment with 7,8-DHF or vehicle, sociability (D: n = 5 and 6, 8 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,32= 16.84, P = 0.0003, two-way ANOVA; **, P < 0.01; Bonferroni’s post-test), and preference for social novelty (E: n = 5 and 6, 8 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,32= 8.89, P = 0.0055, two-way ANOVA; *, P < 0.05, Bonferroni’s post-test). (F and G) Sociability and preference for social novelty at 13 wk (Test 3) after final chronic treatment with 7,8-DHF or vehicle; sociability (F: n = 5 and 6, 8 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,32= 20.13, P < 0.0001, two-way ANOVA; **, P < 0.01; Bonferroni’s post-test), and preference for social novelty (G: n = 5 and 6, 8 for WT and VRK3-KO mice; WT vs. VRK3 KO F_1,32= 5.04, P = 0.0315, two-way ANOVA; *, P < 0.05, Bonferroni’s post-test). n.s., not significant. All values represent mean ± SEM.