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. 2017 Oct 2;214(10):2817–2827. doi: 10.1084/jem.20171069

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© 2017 Perlin et al.

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Figure 2. — Stromal and endothelial cells in the vascular niche modulate Cxcl12 and Kitlg signaling to regulate HSCs. (A) The mammalian bone marrow contains multiple types of perivascular stromal cells and endothelial cells in the vascular niche. Stromal and endothelial cells are both required to express niche factors Cxcl12 and Kitlg to influence HSC localization, maintenance, retention, and quiescence. Stromal cells express these factors at ∼1,000× greater levels. (B) HSPCs colonize the caudal hematopoietic tissue in the 48 hpf zebrafish. Within the niche, multiple factors influence the expression of niche factors Cxcl12 and Kitlg in the CHT. Vascular endothelial cells require expression of transcription factor tfec and chemokine receptor cxcr1 to regulate expression of kitlgb and cxcl12a, respectively, to control HSPC engraftment and expansion. mmp9 expressed by neutrophils in the niche cleaves cxcl12 to promote HSPC egress and colonization of secondary niches.