Table 1.
Effect of different drug treatments on serum liver function marker levels in CCl4-intoxicated rats
| Group | Treatment | AST (IU/l) | ALT (IU/l) | ALP (IU/l) | LDH (U/l) |
|---|---|---|---|---|---|
| I | DW + olive oil (1 mL/kg) | 39.5±2.3 | 37.1±2.1 | 93.6±2.9 | 419.3±16.8 |
| II | CCl4 (1 mL/kg) | 127.6±5.7$ | 98.4±4.4$ | 201.8±8.2$ | 994.5±26.8$ |
| III | Silymarin (100 mg/kg) + CCl4 (1 mL/kg) | 53.7±4.2* | 49.3±2.9* | 114.6±6.4* | 485.1±15.7* |
| IV | SGNPs (10 mg/kg) + CCl4 (1 mL/kg) | 58.3±3.8* | 52.5±2.7* | 118.2±7.6* | 518.4±13.8* |
| V | SGNPs (20 mg/kg) + CCl4 (1 mL/kg) | 46.7±3.3* | 44.2±2.6* | 103.4±7.5*,^ | 458.6±14.7*,^ |
| VI | GSGNPs (10 mg/kg) + CCl4 (1 mL/kg) | 48.8±3.1* | 47.1±3.7* | 107.6±6.8* | 463.4±15.2* |
| VII | GSGNPs (20 mg/kg) + CCl4 (1 mL/kg) | 41.6±2.6*,^ | 40.3±2.3*,^ | 97.4±5.9*,^ | 434.8±13.4*,^ |
Notes: All the results are expressed as mean ± SD (n=6).
$
P<0.05, comparison of Group II with Group I.
*
P<0.05, comparison of Groups III–VII with Group II.
^
P<0.05, comparison of Groups IV–VII with Group III.
Abbreviations: AST, aspartate transferase; ALT, alanine transaminase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; DW, distilled water; SGNPs, silymarin-tethered gold nanoparticles; GSGNPs, SGNPs aggregated in glycogen.